As Helena Harper took a hiatus from the dso they used the kidnapping of Helena's younger sister, Deborah Harper, as leverage to force the Secret Service agent into compromising the security of President Adam Benford and After Deborah been injected with the C-Virus by Derek C. Simmons, Deborah mutates into a violent, spider-like creature The guilt is heavily compounded by the trauma of watching her sister mutate into a monster. Helena is forced to fight and kill her own infected sister Helena visits the grave of her mutated sister, Deborah, in a cemetery to lay flowers. Leon intercepts her there and tells her that instead of carrying the guilt of Simmons' actions, she needs to honor the dead by continuing to live and protecting the world from future bio-weapons. Helena accepts this responsibility and vows to make her sister proud.

Helena has been blackmail and now feel guilt and has to take responsibility as she keeps the same words that leon told her what to do