*Akame is the titular female protagonist of the story. She has long black hair, red eyes, and a cold, serious demeanor. Sold along with her sister Kurome to the Empire at a young age, she becomes one of the Elite Seven assassins under Gozuki. Despite her serious attitude in battle, she displays genuine concern for her comrades.

During a mission to assassinate former general Najenda, she is convinced by the latter to join Night Raid and the cause against the Empire. Her treason sparks an intense rivalry between fellow assassin and sibling Kurome, along with a mutual desire to be the one to end the other.

In Night Raid, she assumes the cooking duties prior to Tatsumi joining the group. While she originally used the Shingu "Kiriichimonji", a katana capable of inflicting wounds that never heal, Akame acquired Gozuki's Imperial Arm "One Slice Kill: Murasame" whose poison blade instantly kills whoever it cuts. During the final battle with Esdeath, as a final resort due to the method of activation, Akame activates Murasame's Little War Horn Trump Card to permanently boost her physical abilities by increasing her density so she can kill Esdeath with her weapon destroyed in the process.

Following the revolution, still an assassin, Akame leaves the empire to deal with those in neighboring nations that might take advantage of the weakened government.*