During a nuclear test, the French government inadvertently mutates a dinosaur nest murged with human DNA; years later, a giant dinosaur humanoid makes its way to New York City. Zach Loud, Rita and Lynn Sr.’s son and Lincoln, Lori, Leni, Luna, Luan, Lynn, Lucy, Lola, Lana, Lisa and Lily’s brother and missed his late big sister Samantha Loud, is sent by the U.S. government to study the beast. When the creature, dubbed "Girlzilla" by news outlets, emerges, a massive battle with the military begins. To make matters worse, Zach discovers that Girlzilla has laid a nest of 200 eggs, which are ready to hatch.