*In "Dr. Klaustus", Roger comments that Reese Witherspoon plays to her strengths by appearing in middle-of-the-road comedies like Sweet Home Alabama. in the same episode, he mentions that Reese Witherspoon's kids come from a broken home, referencing her divorce from Ryan Philippe in 2007, however at the time the episode aired, she was remarried to Jim Toth.

Steve plots to get close to a girl he's infatuated with in "Smooshed: A Love Story" during a class trip to Philadelphia by sitting next to her on the bus and supplying her with milk, which she seems to love. When he is beaten out sitting next to her, he's forced to sit next to Ali, who has a taste for ghost peppers. When he tries one of her peppers without thinking, he creates a scene and covers himself in the milk he was bringing, but does get the girls' attention. After getting some private time with her, he admits that he's in love with her only for her to reveal that she's really Reese Witherspoon trying to prove that she still young enough to pass as a teenager for a part in the film by getting a teenage boy to fall for her. She furthermore admits that she hates milk before jumping off the roof of the building with a parachute.*