After rescuing his old friend, Skyfire, he had explained that he plans to one day take over the role as decepticon leader and make Skyfire his second. However, he sees that his friend wasnt up for killing 'innocent' lifeforms. "I am a scientist, not a killer, they have done no wrong." Skyfire would say.

"But you have, traitor!" Starscream blasted his friend in the back and then left the autobots alone as well as an injured Skyfire.