*Jessica W. of the Prime Dimension was the original version of the current Jessica. She was the first victim of the love potion. She unknowingly doomed humanity by spreading the virus, before mutating into a Cronenberg.

Jessica plays a pivotal role in the episode "Rick Potion #9", where Morty uses a "love potion" concocted by Rick to attempt to make Jessica fall in love with him, in which the potion succeeds. However, the strand of the Flu Virus that Jessica carries infects the school and eventually the world. Due to this, Rick and Morty flee to Dimension C-131, almost identical to the Prime Dimension, but the love potion virus was fixed by the Rick from this dimension.

Jessica was a pretty attractive young teenage girl with shoulder-length, ginger or orange hair who was taller than Morty Smith. She wore a pale cyan headband, a form-fitting, periwinkle polo, a box-pleated, mauve miniskirt, pale cyan mid-calf socks, and plain white loafers. However this was cut short after she mutated into a Cronenberg.

Not much is known about her Cronenberg appearance.

Jessica was a very approachable and well-meaning person who welcomed Morty without any contempt, despite their popularity difference. She seemed to consider abnormal things interesting, remaining surprisingly calm in various situations that would drive others crazy. In the Pilot, she is impressed with Morty for coming into the cafeteria through a portal. However, after being infected with the love potion, she became insanely obsessed with Morty, to the point where she begged him to have sex with her (despite being in public), and dumped Brad for him.*