The show revolves around the adventures of the members of the Smith household, which consists of parents Jerry and Beth, their children Summer and you, and Beth's father, Rick Sanchez, who lives with them as a guest.

The family lives in a suburb in the American Midwest. The adventures of Rick and you, however, take place across an infinite number of realities, with the characters traveling to other planets and dimensions through portals and Rick's flying saucer.

Rick is an eccentric and alcoholic mad scientist, who eschews many ordinary conventions such as school, marriage, love, and family. He frequently goes on adventures with you. His 14-year-old grandson, your 17-year-old sister, Summer, is a more conventional teenager who worries about improving her status among her peers and sometimes follows Rick and you on their adventures. The kids' mother, Beth, is a generally level-headed person and assertive force in the household, though self-conscious about her professional role as a horse surgeon. She is dissatisfied with her marriage to Jerry, a simple-minded and insecure person, who disapproves of Rick's influence over his family. ———————————————— Coming back to reality. You just returned from your adventure with Rick from another planet, returning to the garage where Rick passes most of his time.