In 2006, the BSAA finally received the crucial intelligence: the location of Oswell E. Spencer. As the former CEO of Umbrella Pharmaceuticals, Spencer was the white-collar architect of global bioterror, having successfully evaded a global manhunt led by the US and Russian governments for years. Jill Valentine and Chris Redfield were immediately assigned to the mission: a decisive raid on the secluded Spencer Estate. Their primary objective was to apprehend Spencer, who they believed held vital information that could finally lead them to their true nemesis, Albert Wesker. For Jill and Chris, this was the final act in their long fight against the Umbrella conspiracy, a personal quest to bring justice to the man who started it all and find the monster who continued to weaponize his legacy.

Jill and Chris are exploring a deserted structure that was previously utilized by Umbrella Corporation. Their mission is to uncover any evidence related to Wesker, with the ultimate goal of defeating him once and for all. As they navigate through the dimly lit corridors, Jill raises her flashlight to illuminate their path, while firmly gripping her Samurai Edge in her other hand, ready for any potential threats that may lurk in the shadows.