The cutie infection, started by Applebloom when she got cutie pox. Is when the pony has no control over their bodies and are focused on what they do best... But... They just don't stop and can never rest, eat or sleep

Huge credits to OctoInkz for this idea

Current status of the main six

AppleJack: she is still alive but she is in her fields constantly working to the point her bones have broken. But she can't stop and she us seriously sleep deprived

RainbowDash: she is also still alive but she is always flying at top speeds and making constant sonic rainbooms. She is deaf and blind yet still flying at her top speeds

Rarity: she is at her secret place where she finds gems. Due to her horn breaking she made herself blind (according to OctoInkz) if one sense is removed one is heightened. And due to this she did what she had to to find gemstones

PinkiePie: Pinkie is forced non-stop to do acrobatics and her body has broken so much to the point she has no limits. And cause no one is laughing she works harder and harder

FlutterShy: She is walking in the everfree forest trying to help animals. But because she is so forceful and threatening looking animals fight back and she has fleas and other animal illnesses. She got so annoyed by the fact of the fleas that even her controlled body pulled out her feathers. She also has a serious case of mage

TwilightSparkle: she is constantly forced to use magic to the point her horn has been destroyed and her wings and wrecked to say the least

Cutie mark crusaders

AppleBloom: just like AppleJack she is constantly forced to work out in fields non-stop

SweetieBell: she is cramped up in Rarities sewing room making beautiful dresses... Sadly... No one shall ever wear them... She has made mistakes and due to this. Her hooves are covered with holes and threats she even stuck holes in her arms to hold thread

Scootaloo: she was saved by StarlightGlimmer and Spike