The Second Guest was once a young woman who checked in on the way back from her best friend's wedding, where said friend married the Guest's ex-boyfriend. The Second Guest is a smoker (ticking off Hell's Chef more than once) and has issues with anger. Her ultimate fate was becoming a resident of the hotel and apparently being welcomed into Gregory's family; turning into the female mouse she is today.

She’s a female mouse with blonde hair, blue eyes, red lipstick, a red shirt, & blue jeans.