Jinx: She is mentally unstable, yet brilliant, teenager who struggles with post-traumatic stress disorder (PTSD), psychosis, and potentially borderline personality disorder (BPD), stemming from past traumas and manipulation, evolving from the innocent Powder into a chaotic, yet creative, criminal and she is the younger sister to Vi who she got abandoned

Vi: She is tough, cocky, and hot-headed Zaunite vigilante, known for her protective nature towards her sister, Powder/Jinx, and her initial lack of respect for authority, though she develops a more nuanced and pragmatic side and she is the oldest sister to Jinx

Mel: She is a brilliant, ambitious, and outwardly cold-hearted councilor who prioritizes diplomacy and intellect over brute force, ultimately seeking to secure power and elevate her family through manipulation and strategic planning

Ekko: He is level-headed, resourceful, and compassionate young man from Zaun, driven by a strong sense of justice and a belief in the potential for good, even in the face of adversity

Silco: He is ruthless and brutal, yet highly intelligent and cautious man who was willing to do anything to carry out his ambitions and he actually cared for Jinx like she was his own daughter

Jayce: He is a charismatic, idealistic, and somewhat naive brilliant inventor who initially focuses on the potential of Hextech to improve Piltover, evolving into a complex leader grappling with the challenges of progress and leadership

Viktor: He is brilliant, idealistic, and altruistic scientist, driven by a passion for improving lives through science and technology, particularly the use of Hextech. He is a humble and compassionate man who initially struggles with his own health and the limitations of his body, leading him to pursue scientific advancements to enhance his capabilities

Caitlyn: She is privileged, yet ambitious and justice-driven young woman who, despite her family's expectations, chooses to become an Enforcer, eventually forming an unlikely partnership with Vi