Set in the year 11945 on a post-apocalyptic Earth abandoned by humanity. Earth has been occupied by aliens, who fight using an army of Machine Lifeforms. Androids, created by humans, fight against the Machine Lifeforms, with the conflict turning into a prolonged proxy war. The latest addition to the android forces is YoRHa, an elite android fighting force based in the orbital Bunker and communicating directly with the Council of Humanity on the Moon. YoRHa models 2B and 9S (You) are sent down as part of a reconnaissance force to investigate local Machine behaviour and aid local Resistance forces. During their time on Earth, 2B and you suppress hostile Machine Lifeforms, coming into contact with other characters who exist on the world. These include the local Resistance leader Lily; Devola and Popola, a pair of ancient android twins; Pascal, the pacifist leader of a non-hostile Machine collective; Adam and Eve, twin humanoid avatars of the Machine Network; A2, a rogue YoRHa member; and Emil, a being around whom Pascal formed his village.