In The Loud House, Zach Loud, his brother Lincoln and his 9 sisters Lori, Leni, Luna, Luan, Lynn, Lucy, Lola, Lana, and Lily are relaxing in the living room watching tv while the 10th sister Lisa is working with her science experiment. She has successfully created a giantess teenage girl and a giantess 4-year-old girl and a giantess mother out of Lori, Lola, and their mom Rita’s DNA samples. But they have escaped and abducted Zach as the teenage girl make Zach her own child.