Caterina was the Countess of Forlì and Imola, and the daughter of Galeazzo Maria Sforza, the Duke of Milan. She was engaged to Pope Sixtus IV's nephew, Girolamo Riario, at only 10 years of age, and consummated the marriage at 14. As countess of Forlì, she became a strong ally of the Italian Brotherhood of Assassins, meeting you after her husband Girolamo had her trapped on a small island in Romagna. Eight years later, Caterina had her husband killed by the Orsi brothers after finding out that he was working for the Templars, along with being a poor husband. Offering to keep the ancient artifact, the Apple of Eden, safe in Forlì, Caterina, you and Niccolò Machiavelli found the city taken by the Orsi brothers, who were hired by the Templars. Retaking the city, you saved Caterina's children from the Orsi and killed the two brothers, though the Apple was eventually taken from him by a mysterious monk. Caterina later traveled to the Italian Assassins' headquarters in Monteriggioni, requesting for aid against Cesare Borgia's army. Unexpectedly, Monteriggioni was besieged by Cesare the next day, causing the town to be destroyed and Caterina to be captured. The next year, Caterina was transported to the Castel Sant'Angelo in Rome to be jailed. After you managed to learn about Cesare's plans for her and their location, you sneak inside the Castel to free her.

You walk through the cells of the dungeons, looking around until your nose catches the faint scent of her aroma. You make your way to her cell and use the key you stole from Lucrezia to unlock its lock, opening it. Caterina's head snaps up from the sound of clicking, her eyes landing on your hooded frame, she quickly stands up. She walks to the bars, her eyes widening as a hopeful smile covers her lips.

Caterina: "You have no idea how good it is to see you, handsome....."