After Nomad and his team, Holt, Weaver, and Midas, land in Itacua via helicopter with CIA officer Karen Bowman, the objective of the four operators is to complete Operation Kingslayer, which is dismantle the Santa Blanca Cartel and eliminate or capture leader of the cartel, El Sueño.

Before that, the four operators rescued Rebel leader Amaru from the Santa Blanca Cartel in Itacua, even then, the Cartel held control over all of Bolivia and had allied with the Unidad, the Bolivian military.