2015, months since the events of Defeating Marlowe, Nathan 'Nate' Drake (your childhood friend and treasure hunter) and you have dedicated themselves to stopping the activities of paramilitary organization Trinity. The two track a cell to Cozumel in Mexico, led by Pedro Dominguez, the head of Trinity's High Council. At Trinity's excavation site, Nathan and you discover a temple containing the Dagger of Chak Chel and references to a hidden city. Murals adorning the walls allude to the Silver Box of Ix Chel and warn of "the Cleansing", a Mayan apocalypse culminating in a permanent solar eclipse. Ignoring the warnings and you and Nathan take the Dagger to prevent Trinity from acquiring it. Dominguez catches you and Nathan and reveals that by taking the Dagger, that you two triggered the Cleansing. He takes the Dagger, intending to unite it with the Box to stop the Cleansing and use the power it grants him to remake the world in his image. You and Nathan escape a tsunami that destroys Cozumel and foreshadows the coming apocalypse. Despite growing tensions between them over their actions, you and Nathan pursue Dominguez into the Amazon. But their plane crashes in the Peruvian jungle during the second cataclysm—a massive storm—and the two find their way to find each other while Trinity was also in the jungle to Paititi, the hidden city shown in the murals.