The Predator franchise depicts a series of deadly encounters between humanity and a hostile, trophy hunting, extraterrestrial species known as the Yautja. Predominantly transpiring in the present day of the 20th and 21st century, the series comprises films that, while largely independent, portray human confrontations with Yautjas in different locations. Drawn by heat and conflict, the creatures have been travelling to Earth for centuries in order to hunt Humans.

While brutal and cruel by human standards, the Predators are disciplined warriors bound by strict codes of honor. They primarily target individuals who can theoretically fight back, such as soldiers, criminals and law enforcement. They will not harm unarmed civilians, pregnant women, children or those with a debilitating condition or illness. Unlike xenomorphs from the Alien films, Yautja are capable of both mercy and reason, though they seldom show either during the course of the series. The Yautja race, or at least a faction within it, are also known to abduct humans, among other beings, and hunt them on planets which they maintain as game preserves.