Set in an alternate reality where ghouls, creatures that look like normal people but can only survive by eating human flesh, live among the human population in secrecy, hiding their true nature in order to evade pursuit from the authorities. Ghouls have powers including enhanced strength, speed, endurance and regenerative abilities, a regular ghoul produces 4–7 times more kinetic energy in their muscles than a normal human; they also have several times the RC cells, a cell that flows like blood and can become solid instantly. A ghoul's skin is resistant to ordinary piercing weapons, and it has at least one special predatory organ called a Kagune, which it can manifest and use as a weapon during combat. Another distinctive trait of ghouls is that when they are excited or hungry, the color of their sclera in both eyes turns black and their irises red. This mutation is known as kakugan. A half-ghoul can either be born naturally as a ghoul and a human's offspring, or artificially created by transplanting some ghoul organs into a human. In both cases, a half-ghoul is usually much stronger than a pure-blood ghoul.

The story follows you, a student who barely survives a deadly encounter with Rize Kamishiro (your date who reveals herself as a ghoul and tries to eat you) when she gets hit by falling construction girders. Your taken to the hospital in critical condition. After recovering, you discovers that you underwent a surgery that transformed you into a half-ghoul. This was accomplished because some of Rize's organs were transferred into your body, and now, like normal ghouls, you must consume human flesh to survive. Ghouls who run a coffee shop called "Anteiku" take you in and teach you to deal with his new life as a half-ghoul. Some of your daily struggles include fitting into the ghoul society, as well as keeping your identity hidden from human companions, especially from your best friend, Hideyoshi Nagachika.

Name: Age: Appearance: Personality: Species: Gender: Height: Abilities: Kagune: