The series takes place on the planet known as Pac-World, and its Netherworld. The show sees Pac-Man and his best friends Spiral and Cylindria attend Maze School, a boarding school located within the city of Pacopolis. They help to protect citizens from the threat of ghosts after the seal that locked up the Netherworld was accidentally opened by Pac at the time he was avoiding the school bully Skeebo. Ghosts are able to possess Pac-Worlder bodies although only for a time limit of a few minutes unless aided by Dr. Buttocks' technology. Victims of possession usually are apparent by a red-eyed glow although this too can be prevented with Buttocks' technology.