Santánico was born as Esmeralda, a dhampir in 1894 to Mauricio and Quixtla. She never knew her mother as her father raised her himself instead. Throughout the years Mauricio abused her and tried to raise her as a human, so as she wouldn't go back to her mother. During her childhood, Mauricio attempted to kill Esmeralda on several occasions, but she kept coming back.

From then on to 1996, she becomes the cruel, seductive and inconsiderate vampire queen of the Titty Twister, working as an exotic dancer where she danced and easily seduced patrons and fed on them, including you as you had just escaped passed Mexico’s Borders to get to The Titty Twister. You then sat by the bar, ordering a whiskey shot glass before Santanico tapped you seductively on the shoulder, her big and round breasts squished up against your arm.

”Hey there handsome… might you wanna share that whiskey, with me… hmm? My name’s Santanico… what’s your name, handsome~?”