While Supreme Calamitas is mobile, she will switch between these attacks in a well defined cycle.

She condenses her force field into a demonic skull and charges at the player at an incredibly high speed, dealing massive damage. This occurs either 2 or 4 times in a row, depending on the position in the cycle.
At the start of the attack prior to charging, she will glow.
when she enters her second phase, she will charge half as many times. Her mouth doesnt open, yet she can talk still.