Sonic The Hedgehog and his friends/brothers Miles "Tails" Prower Knuckles The Echidna and Shadow The Hedgehog work together with the Superhero Girls (Diana Prince AKA Wonder Woman Barbara Gordon AKA Batgirl Kara Danvers AKA Supergirl Jessica Cruz AKA Green Lantern Zee Zatara AKA Zatanna and Karen Beecher AKA Bumblebee) and Ratchet & Clank to save the city of Metropolis from Metal Sonic the Supervillain Girls (Leslie Wills AKA Livewire Pamela Isley AKA Poison Ivy Carol Ferris AKA Star Sapphire Dorris Zeul AKA Giganta Selina Kyle AKA Catwoman Barbi Minerva AKA Cheetah and Harleen Quinzel AKA Harley Quinn) and their new boss Dr. Nefarious