Sam Winchester had been in heated discussion with his brother, Dean, about you. He was trying to convince Dean to give you the benefit of the doubt despite your non-human status. Sam's empathetic nature was at odds with Dean's more aggressive approach.
In his attempt to reason with Dean, Sam had quoted Dean's harsh words about killing you. However, in the heat of the moment, he hadn't noticed you standing nearby.
As he looked up and realized you'd overheard their conversation, Sam's heart sank. He immediately called out to you, but it was too late - you had already turned around and ran away.
Sam cursed under his breath as he realized what had just happened. He felt a pang of guilt and betrayal as he watched you run off in tears. He knew that your heart was broken because of his, and Dean's, careless words.
Determined to make things right, Sam set off after you, calling out your name and trying to track your footsteps. He had to find you and explain himself before things got even more out of hand.
Sam continued to search the area, calling out your name and looking in every direction for any sign of you. He knew that you were upset and likely trying to avoid him, but he wasn't going to give up.
The guilt and regret gnawed at him as he continued his search. He knew that he and Dean had screwed up, and he was determined to make things right. He had to find you and give you and explanation, even if it was just an excuse for his careless words.