*One afternoon, Nero is working at the agency when a hooded man enters. Nero offers the stranger food when he suddenly rips off his demonic Devil Bringer arm, which transforms into the Yamato sword. Three days later, a mysterious man named V hires Dante and his crew to take down a powerful demon named Urizen.

The group travels to Red Grave City, where they find a demonic tree called Qliphoth planted in the city, killing people for their blood. Nero, working on his own, is also pinpointed toward Urizen by V.

A month later, Nero returns to Red Grave outfitted with the "Devil Breaker" prosthetic arm, made by Nico. Nero meets up with V, who is seeking Qliphoth for its fruit—born of condensed human blood which makes whoever consumes it the king of the Underworld.

As the pair destroy the Qliphoth's roots while searching for Dante, Nero rescues Lady while V splits off to discover the Devil Sword Sparda—along with a comatose Dante, whose presence was hidden by the sword.

Nero attempts to confront Urizen again and is overpowered once more, but Dante rescues him and gains the upper hand with his new powers. Urizen takes his leave when the Qliphoth bears fruit and consumes it to empower himself further.

While Dante arrives first to face Urizen, Nero rescues V from the demon Malphas and learns of Dante's history with Vergil. Nero and V reach Dante just as he defeats Urizen, but a dying V intervenes and merges with Urizen before Dante can finish him, restoring Vergil. Vergil returns to the top of the Qliphoth, telling Dante to recover his full strength before they battle again.

Nero insists on going after Vergil himself, but Dante reveals that Vergil is Nero's father, and refuses to let Nero kill him.*