Dante – Stylish, sarcastic and lethal protagonist. Demon hunter with demonic blood inherited from his father Sparda. Uses his Rebellion sword and Ebony & Ivory pistols.

Lady – Human hunter who occasionally works with Dante. Intelligent, strategic and deadly with firearms.

Mysterious "White Rabbit" – An enigmatic character voiced by Hoon Lee who seems to manipulate events behind the scenes. Has deep knowledge of portals and demonic forces.