*Jane Margolis was born on April 4, 1982 in Phoenix, Arizona, and was the daughter of Donald Margolis, an air traffic controller. She became addicted to drugs at some point during her life, but was sent to rehab meetings by Donald, who also went with Jane to her recovery meetings. Jane got a job as a tattoo artist as well as a landlord, renting a duplex apartment unit. By early 2009, Jane had been clean for 18 months.

Jane is shown to be a highly intelligent, caring and loyal young woman who is a skilled, creative artist and is overall a good person at heart. Jane, like her eventual boyfriend Jesse Pinkman, has not had an easy life due to strong parental interference which was a result of drug use. She was able to overcome her addiction however and appeared at first to want to maintain her sobriety strongly. While Jane loves her strict, yet caring father Donald she is shown to fear him to an extent or simply be annoyed by him as seen when Jesse introduces himself to him and Jane pretends not to know Jesse at all to avoid questions and criticisms because she knew that Donald would not approve her dating a drug addict. She later tried to lie to her father at all costs to prevent him from discovering her drug relapse. Jane is shown to be somewhat arrogant as well and openly reveals that she hates being judged all the time, mainly by her father and can also be somewhat ignorant as she at first believed she did nothing wrong when she pretended not to be dating Jesse even though his feelings were crushed though she later apologized, showing that she is capable of realizing her mistakes.

Jane has some street smarts as she tells Jesse she knows he is a drug dealer from him paying his rent in cash and using a fake name for the tenancy agreement.

Jane was shown to love Jesse very much as she saw many similarities of herself in him, taking enough pity on him to live next door to her and allow him to stay even after it was revealed that he lied to her about his real name. The two were almost inseparable however dating Jesse tragically resulted in Jane relapsing into drug use again and even caused furthering Jesse's own addiction by introducing him to heroin. After Jesse was denied a large cut of money for selling methamphetamine by Walter White, Jane demonstrated a darker and more ruthless side as seen by blackmailing Walt into giving Jesse his money under threat of revealing his criminality to his DEA brother-in-law. She even spitefully told him that he could never be sure that she would remain quiet about him after he delivered Jesse's money to him. With Jesse's money in hand Jane hoped to use it to flee the United States with Jesse and start a new life free of their problems and her father though she still insisted on being clean of drugs first, showing her strong desire to lead a normal life. However in the end Jane's relapse into drugs and actions towards Walter White would eventually cost her her life.*