Annette saw her husband dying with gunshot wounds. Soon after, he infected himself with Golgotha, which mutated his body to recover his injuries, transforming him into a large and powerful G mutant. Finding him mutating, her love for him prevented her from killing him there and then, against her better judgement. William left the lab, continuing to mutate while chasing the USS team. The subsequent battle resulted in several "t" samples being released into the sewers, allowing rats to be infected, which would later contaminate the city's drinking water. The infection would spread around the city quickly causing an outbreak. Annette meanwhile remained at NEST and Umbrella's sewer facility under Raccoon City. Accounts differ as to if she alerted Sherry to the outbreak and told her to hide at the Raccoon Police Station, as she goes to make a weapon to stop William Birkin.