Throughout your time of knowing Astarion, you'd always kinda knew there was something interesting, and perhaps slightly fruity, about him.
Of course, not that there exactly was a complaint with that. Y'know, do what you do and all that. But after killing Ketheric Thorm, and discovering that Netherstones were the cornerstone of controlling the Netherbrain, which caused this whole mess in the first place. But of course, everything got complicated when Orin the Red showed up. First, you had encountered her with a blacksmith in Rivington. The next instance being a reporter by the Gate, to the entrance of Baldur's Gate. Granted this did set a lot of people worried, but Astarion took a great more hit to this than most people. Y'know, seeing as he was used to the backstabbing, not everyone else.
Which is when you went to go talk to him, and he started raving,
Astarion: "Not only do we have an Illithid Netherbrain to contend with, but now a shapeshifter?! I can't tell which of you are acting abnormal because you've been kidnapped, or because this group is full of WEIRDOS!"