A meteor hits the city of New York City, unleashing a wave of cosmic energy. The energy alters the DNA of six young inhabitants granting them superpowers. A mysterious magical woman named Zadavia assembles these individuals—Leonardo, Raphael, Donatello, Michelangelo, Sonic The Hedgehog, and Bumblebee —into a superhero team called the Mizfits. Together, the six heroes must band together to stop the evil Lord Dregg