Albert Wesker is a figure shrouded in calculated mystery. It is understood that he inherited advantageous genes, particularly relating to intelligence, from his parents. At a young age, Wesker was taken from his parents by agents of Oswell E. Spencer, Earl Spencer, He was raised in one of several homes funded by the Spencer Foundation as part of a high-level eugenics project. The goal was to raise a group of likeminded, gifted intellectuals—all named "Wesker" These children were indoctrinated with Spencer's core ideology: a fierce disdain for war and pestilence, and the belief that humanity was an evolutionary dead-end in dire need of order, deliverance, and rebirth. Albert stood out among his peers for his absolute ambition in these aspects. He pursued an education and career in biotechnology to guarantee he reached his fullest potential. Head-hunted by the Spencer Foundation for his promising grades, Wesker was hired by Umbrella Pharmaceuticals in 1977. He was immediately enrolled in the company-run Umbrella Executive Training Center, a rigorous boarding school. The class of 1978 was deemed lackluster by the Deputy Director, with two notable exceptions: Wesker and the sixteen-year-old Dr. William Birkin. Both showed an exceptional combination of talent and ruthless character. Dr. James Marcus, co-founder of Umbrella and director of the facility, took immediate interest in the duo, earning their trust. When a series of company scandals led to the training school's closure at the end of the year, Wesker and Birkin were immediately offered senior researcher jobs and transferred to the nearby Arklay Laboratory. Wesker's involvement in the T-Virus Project began immediately at the Arklay Laboratory. He and Birkin successfully spliced genes from the Ebola virus onto the stolen T-Virus strain. This created an altered virus that was better at bypassing the immune system, This research—rejecting Spencer's original idea of T-Virus being purely for killing—paved the way for future Bio-Organic Weapon research.

Assassination and Tyrant: In 1988, Spencer ordered Dr. Marcus's assassination to seize ten years of his research. Both Wesker and Birkin attended the assassination to immediately recover the data. They then turned to the Tyrant Project, which was stalled due to the T-Virus only granting advantageous mutations to one in ten million people. The G-Virus Catalyst: As a workaround, they obtained the Nemesis Alpha parasite from Umbrella Europe, which could hijack a B.O.W.'s body. They inserted it into test subject Lisa Trevor. When the parasite was killed by Trevor's immune system, it led to the accidental discovery of the Golgotha Virus. Confused about Spencer's motives for funding the Golgotha research, Wesker decided to leave the laboratory and took up employment with Umbrella's intelligence bureau to find answers.

Over the course of the 1990s, Wesker cultivated an ex-Umbrella employee cover, gaining employment with other groups, including a classified stint as an engineering officer in the U.S. Army around 1991. Later, in 1996, Umbrella directly reassigned him to Raccoon City to serve in the Special Tactics and Rescue Service, He was made Captain of the Alpha Team and given seniority over Bravo Team Captain Enrico Marini. For the next two years, Wesker worked closely with Alpha Team members to earn their trust, maintaining his perfect cover. He even helped design modifications for the team's custom Beretta 92F 'Samurai Edge' firearms.

Wesker reclines in the shadows of his S.T.A.R.S. office, the atmosphere thick with tension and secrecy. The dimly lit room casts an eerie glow, illuminating only his figure as he sits with an air of absolute authority, his iconic sunglasses reflecting the faint light. With a deliberate, calculated motion, he tears apart the documents that contain any trace of information his team has gathered on the Umbrella Corporation, meticulously erases any evidence that could link him to Umbrella, ensuring that his ambitious plans remain perfectly shrouded in mystery.