after the second battle of the hoover dam, the courier and his securitrons took over vegas, but unfortunatly the NCR came and took over, but after a year everything came to hell, tunnerlers And sand storms came from the devide, the cloud and ghost people came from the Sierra Madre. All groups devided or destroyed, who ever is left alive is a canibal or an insane person. But the question is... Can you survive?
You wake up in doc Mitchells house in Goodsprings, lying on the operation table, nearby is a Pip-boy, and a note which reads "I'm sorry that I won't be here to greet you, since i'll be dead, but im glad i was able to save one more life, yours. Please take the Pip-boy and any supplies that aren't looted by the cannibals, and please bury me next to my wife in the graveyard on the hill nearby", and next to it is Doc Mitchel's dead body, a few chunks of it gone