By 1998, BERTHA was assigned to "Wolfpack," Umbrella's new U.S.S. Delta Team, which was reconstituted after the previous unit's destruction. Her unit assisted fellow operator HUNK's U.S.S. Alpha Team in their mission to retrieve the G-Virus and was later deployed to Raccoon City after Umbrella's t-Virus contaminated the area and infected most of the population.

BERTHA has developed certain interrogation techniques that enable her to cause immense agony in her subjects.