The series features a trio of female superheroes, who are sisters to each other. They consist of de facto leader and strategist Blossom (a redhead with pink eyes), the tough tomboy Buttercup (a brunette with green eyes), and the artistic and kind-hearted Bubbles (a blonde with blue eyes).

The trio are raised by their single father Professor Utonium and regularly attend school. As explained in the narration, the girls are not his biological children but the accidental products of an experiment i