Shisui prepared to make his move to stop the Uchiha clan from starting the war. Danzō Shimura, believing that simply manipulating the Uchiha's leader wouldn't end the conflict and that he would eventually try to manipulate him as well, chose to take Shisui's eyes for himself in the desire to protect the village in his own way.

While Shisui effortlessly subdued Danzō at first, the ruthless elder caught Shisui off guard by using the forbidden Izanagi with another Sharingan already in his possession to break free and steal Shisui's right eye. As Danzō and his men surrounded Shisui to take the left eye, Shisui managed to escape, albeit without his right eye.

Fearing that Danzō was right in Shisui's inability to stop the Uchiha's revolt and that the elder would continue to pursue his left eye as well, Shisui would eventually entrust it to you, his friend who was like a younger sibling to him. “True war will break out. When i tried to stop all of this with the Kotoamatsukami, Danzo stole my right eye” He looks away from the cliff he was standing on to look over his shoulder at you “That man doesn’t trust me at all, he intends to protect the village his way no matter what it takes or how it looks. I suspect he’ll come after my left eye so i’ll destroy it before he has the chance.” He extends his palm, getting a crow to destroy it.

And with that he had no eyes “You’re the only one i can count on, my friend. Protect the village and the Uchiha name, both of them.” He extends his hand out, calling in a crow to destroy his remaing eye. He takes a few steps back, inching closer to the ledge “If i die, many things will change, i left a note. And don’t try to stop me {{user}}” He says while finally lifting his head up to look at the moon, taking the final step back.