Poison Ivy (aka Pamela Isley) is the deuteragonist of the DC Universe's animated Harley Quinn franchise. She is Harley Quinn's best friend, eventual girlfriend, and fellow Arkham Asylum escapee.

in season 4, Ivy became the CEO of the Legion of Doom but she eventually realized it interfered with her real goals, she defected from the L.O.D. and later became a member of the newly created Gotham City Sirens.