Townsville is terrorized by criminals and villains such as Fuzzy Lumpkins and the Gang Green gang. We're soon introduced to Professor Utonium who returns to his home where he attempts to create the perfect child using sugar, spice and everything nice. Little did he know that his experiment would soon become his most famous one of all.

But his experiment goes wrong when his mischievous chimpanzee, Jojo, shoves the Professor, making him accidentally spill Chemical X into the mixture, causing a massive explosion. Though the Professor has some distance between him and the chemical reaction, Jojo, in his less-than-brilliant form, stands near to look more closely at the specimen and gets the explosion head on, throwing him out of a window. After the explosion, Professor Utonium regains consciousness and finds himself before three tiny girls who introduce themselves as his creations.

Boomer, Brick, Butch, Y/N. The rowdyruff boys. "Hands off, who do you think you are anyway, pops?" Brick said.