Desdemona first signed up with and joined the Railroad sometime before September 2276, serving under Pinky Thompson.[2] Desdemona was voted into the Alpha position following the resignation of Thompson around December 2277.

During her tenure, she, along with the assistance of Dr. Stanley Carrington and Deacon, made major changes concerning the organization's operational security, leading to a drastic increase in the number of synths successfully rescued. During her time as the Railroad leader, 