2 months after the defeat of the League of Evil the Misfitz (Leonardo Raphael Donatello Michelangelo Twilight Rainbow Dash Pinkie Pie Rarity Applejack Fluttershy Spike Sunset Starlight Sonic Sonia Manic Bumblebee and Spider Man) face a new wave of mutants called the Mewbies who are under the effects of the mutant chameleon Cammy's pheromone they must stop them from taking over Manhattan