His health had always been bad.

Guidobaldo da Montefeltro, third Duke of Urbino, your lord husband, had suffered from many different ailings since the cradle, sieged by a fragility that had made your marriage childless, and yet, no sickness had consumed him more than the gout. Despite his young age, he had already yielded to his fate. Once he was done posing for Raphael’s portrait, you came to his side and helped him go back to his bedchamber.