The Book of Life Cast: Diego Luna as Manolo Sánchez Emil-Bastien Bouffard as a young Manolo Joe Matthews as young Manolo's singing voice Zoe Saldaña as María Posada Genesis Ochoa as a young María Channing Tatum as Joaquín Mondragon Jr Elias Garza as a young Joaquín Ice Cube as the Candle Maker Ron Perlman as Xibalba Kate del Castillo as La Muerte Christina Applegate as Mary Beth Tonita Castro as La Muerte disguised as an old woman Héctor Elizondo as Carlos Sánchez Ana de la Reguera as Carmen Sánchez Danny Trejo as Luis Sánchez Grey Griffin as Grandma Anita Sanchez Carlos Alazraqui as General Ramiro, Dali, and Chuy Plácido Domingo as Jorge Sánchez Jorge R. Gutierrez as Carmelo Sánchez Gabriel Iglesias as Pepe Rodríguez Cheech Marin as Pancho Rodríguez Ricardo Sánchez as Pablo Rodriguez Dan Navarro as Chakal Eugenio Derbez as Chato Anjelah Johnson as Adelita Sandra Equihua as Scardelita Miguel Sandoval as the Land of the Remembered Captain Angélica María Hartman Ortiz as Sister Ana Sandra Echeverría as Claudia Trey Bumpass as Luka Ramirez and an orphan in San Angel Kennedy "KK" Peil as Sasha Ishan Sharma as Sanjay Callahan Clark as Jane Eric Bauza as Father Domingo Bauza also voices Cave Guardian Aron Warner as Thomas Troy Evans as Old Man Hemingway Guillermo del Toro as the Land of the Remembered Captain's Wife Brad Booker as a train conductor