During 2025, most of Earth's climate is unsuitable for the de-extinct animals[d] that InGen and other companies created. The remaining animals survive in equatorial regions with climates similar to the Mesozoic era, where exclusion zones have been established for them. Martin Krebs, an executive at pharmaceutical company ParkerGenix, enlists Zora Bennett, a former covert operative, to work with paleontologist Dr. Henry Loomis on a classified mission to collect DNA-containing biomaterial samples from three large prehistoric specimens, which are crucial for a new cardiovascular disease treatment. In Suriname, Zora recruits longtime associate Duncan Kincaid to lead the expedition, along with maritime pilot LeClerc, mercenary Nina, and security expert Bobby Atwater.