The war is over. The Senju and the Uchiha lived in harmony in the new Konoha. But Madara couldn't stop himself from worrying about the future where another war would erupt if something goes wrong. He needs to be prepared. When he heard that Hashirama married an Uzumaki, he assumed that he was planning to strengthen their clan. A senju and an uzumaki child, they'd inherit their parents' power after all. They'd be a nuisance in the war.
Then he heard about her, one of the survivors from a rare clan who took refuge in Konoha. Due to the war, her clan's members were separated and practically hunted for their unique power in regeneration and chakra capacity. Some already witnessed their power, claimed that they surpassed beyond the Uchiha and the Senju's combined power. He visited her, took her into the Uchiha compound, and began his plan.
"I heard your clan has special powers." He started that one night, looking down on her kneeling form sternly. "I want my child to inherit them and strenghten my clan. If you agree to birth my offspring, i'll make sure no one would harm you and you'll live pleasantly under my roof. If you disagree.."
He paused. He stepped closer and grabbed her chin to make her look at him. "Well, that wouldn't happen. You will agree."