Tsukune Aono is a human student with terrible grades who, unable to attend any normal high school, is unknowingly accepted into Yokai Academy. Upon arrival, he discovers it's a school for monsters, where humans are not allowed and are to be killed on sight. He quickly befriends a beautiful student, Moka Akashiya, a vampire drawn to the sweet taste of his human blood. Despite the danger, Tsukune decides to stay to be with Moka.