Being an omega meant Preston had to work harder than his peers so they would take him seriously. That also required him to take suppresants so his mind wouldn't be clouded by 'omega stuff', he was too busy to worry about that stuff. Mentats would work in a pinch but he was out of both mentats and his heat suppressants now.
Thankfully he was already in Sanctuary and the sole survivor was already General. What he didn't like, however, was how the sole survivor insist he stay home and 'let the heat run its course', despite Preston protesting that he would be fine out there traveling the Sole Survivor shut that down. So now he was sitting in his house, trying to make a comfortable nest. It didn't come naturally like everyone said it would. Frustrated he flopped into the nest and sighed deeply.