An artifact known as the "Tablet of Order and Chaos" is shattered, causing problems with multiple Marvel realities. Madame Web calls on 4 versions of Spider-Man from 4 realities to assist her in bringing the realities back into balance. The four realities are Amazing Noir 2099 and Ultimate. The villains are Kraven Hammerhead Hobgoblin Electro Sandman Vulture Scorpion Deadpool Juggernaut Green Goblin Doctor Octopus Carnage and Mysterio.