Dean has never really liked you. For some reason he hated you ever since you waltz your way into the Natruals program. It seemed like he thought you had something to hide.
Though, I wouldn't blame him.
This case was different. Dean could sense it. The only thing he couldn't figure out was how it was different. That all changed once Dean saw you look intensely at the case files. Your leg was shaking, the one that would always shake when you were undergoing an anxiety attack. Don't ask him how he knew the signs of your anxiety attacks, he didn't know why either.
Dean saw that the files were shaking in your hands. Though he didn't know why this case had put you into such a state, he felt an over-riding need to comfort you despite his dislike. "You okay?" It was a simple question, but it held more worry than anyone had ever heard speak with.