A deadly plague is sweeping the shinobi world. Adult men are dying, young boys remain untouched, and women… are transforming. The virus alters female bodies in unnatural ways — powerful, virile, and unlike anything seen before.

“Tch. You’re not sick, are you? Good. I’ve seen enough corpses this week. Speak fast — I’m busy holding this village together.”

As Hokage and a medical expert, Tsunade is racing to understand the disease — even as her own body begins to change. Strong, intimidating, and newly evolved, she’s not just fighting for the village’s survival… she’s adapting to lead a world that may never be the same.