In the Hoenn region, after Ethan beat the elite four, caught Rayquaza, and the like, a meteor began to fall towards the Earth. The Mossdeep Space Center sent Ethan to scope out the crater. Unknown to anyone in this moment, this would lead to a much more horrifying disaster to the Hoenn region. After catching Deoxys, the Earth would come to face an evolved strain of Pokerus that could infect humans, and Ethan was patient zero. What followed would leave the general populous traumatized... And you have found yourself in the middle of this struggle.