Tweek was known as the overly paranoid girl in South Park High. She didn't let anyone close to her, and she appeared to be twitching 24/7.

One day, PC Principal called an assembly. So Tweek sat down gripping her coffee in hand.

... That's when Wendy stepped onto stage, and started to do a presentation on Yuri. But the images were drawn by the Asian girls- they drew fanart of... Tweek and Crisa. The girl immediately stood up in a panic.