Josuke is a young man afflicted with retrograde amnesia, lacking any memories prior to being discovered by Yasuho Hirose near the Wall Eyes in Morioh Town. He dedicates himself to discovering his former identity and those originally associated with him.

He eventually learns that he did not exist until Josefumi Kujo and Yoshikage Kira fused together with the Locacaca fruit, and is neither one nor the other. Josuke is a Stand User and retains an upgraded version of Josefumi's Soft & Wet.